Background:

(+)-Propoxyphene-d₅(hydrochloride) (CRM) is a certified reference material intended for use as an internal standard for the quantification of (+)-propoxyphene by GC- or LC-MS. (+)-Propoxyphene is categorized as an opioid.¹It is a diphenylheptane analgesic that can have hazardous interactions with other drugs.^2,1,3Propoxyphene is regulated as a Schedule IV compound in the United States. (+)-Propoxyphene-d₅(hydrochloride) (CRM) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.

1.Trescot, A.M., Datta, S., Lee, M., et al.Opioid pharmacologyPain Physician11(2 Suppl.)S133-S153(2008) 2.Codd, E.E., Shank, R.P., Schupsky, J.J., et al.Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: Structural determinants and role in antinociceptionJ. Pharmacol. Exp. Ther.274(3)1263-1270(1995) 3.Opondo, D., Eslami, S., Visscher, S., et al.Inappropriateness of medication prescriptions to elderly patients in the primary care setting: A systematic reviewPLoS One7(8)(2012)