Background:

Nanangenine F is a drimane sesquiterpene fungal metabolite that has been found inA. nanangensis.¹It is active againstB. subtilis(IC₅₀= 78 µg/ml) and cytotoxic to NS-1, DU145, and MCF-7 cancer and NFF non-cancerous cells (IC₅₀s = 49, 95, 49, and 84 µg/ml, respectively).

1.Lacey, H.J., Gilchrist, C.L.M., Crombie, A., et al.Nanangenines: Drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensisBeilstein J. Org. Chem.152631-2643(2019)