An internal standard for the quantification of solifenacin
货号:ajcx25364
CAS:N/A
分子式:C23H21D5N2O2·C4H6O4
分子量：485.6
溶解度:DMSO: soluble,Methanol: soluble,Water: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

carbamoylcholine Solifenacin-d₅is intended for use as an internal standard for the quantification of solifenacin by GC- or LC-MS. Solifenacin is a competitive antagonist of M₁, M₂, and M₃muscarinic acetylcholine receptors (K_is = 25, 125, and 10 nM, respectively, for the human receptors).¹It inhibits calcium mobilization induced by carbamoylcholine in isolated guinea pig detrusor muscle cells (K_i= 4 nM).²Solifenacin inhibits carbachol-induced contraction of isolated guinea pig urinary bladder smooth muscle.In vivo, solifenacin (0.03-1 mg/kg) inhibits carbachol-induced increases in urinary bladder pressure in anesthetized rats. Formulations containing solifenacin have been used in the treatment of overactive bladder.

1.Hegde, S.S.Muscarinic receptors in the bladder: From basic research to therapeuticsBr. J. Pharmacol.147(2)S80-S87(2006) 2.Ikeda, K., Koboyashi, S., Suzuki, M., et al.M3 receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary glandNaunyn Schmiedebergs Arch. Pharmacol.366(2)97-103(2002)