An active metabolite of isotretinoin
货号:ajcx25454
CAS:71748-58-8
分子式:C20H26O3
分子量：314.4
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 15 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

4-oxo Isotretinoin is an active metabolite of the retinoid isotretinoin .¹It is formed from isotretinoin by several cytochrome P450 (CYP450) isoforms, including CYP3A, CYP2B6, and CYP2C19.²4-oxo Isotretinoin (10 µM) increases protein expression of cytokeratin 7 (CK7) and CK19 in normal human epidermal keratinocytes.³It inhibits proliferation of retinoid-sensitive UM-SCC-22A and UM-SCC-35 head and neck squamous cell carcinoma (HNSCC) cells in a concentration-dependent manner.⁴4-oxo Isotretinoin has been found in influent and effluent wastewater.⁵It is teratogenic to mouse embryos when administered to pregnant dams at a dose of 100 mg/kg on day 11 of gestation.⁶

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