A Plk1 inhibitor
货号:ajcx25522
CAS:929095-23-8
分子式:C26H27ClN4O3S
分子量：511
溶解度:DMSO: 25 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GSK579289A is an inhibitor of polo-like kinase 1 (Plk1; IC₅₀= 2 nM).¹It is selective for Plk1 over Plk3 (IC₅₀= 630 nM). GSK579289A inhibits proliferation of HCT116 cells (IC₅₀= 11 nM).

1.Rheault, T.R., Donaldson, K.H., Badiang-Alberti, J.G., et al.Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophenecarboxamides: Potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like propertiesBioorg. Med. Chem. Lett.20(15)4587-4592(2010)