| 包装: | 500ug |
| 规格: | 98% |
| 市场价: | 2189元 |
| 分子量: | 3148.6 |
Background:
Somatostatin-28 is a cyclic neuropeptide hormone that has a role in endocrine regulation.1It is a somatostatin (SST) receptor agonist that binds to SST1, SST2, SST3, SST4, and SST5(IC50s = 0.60, 0.12, 0.22, 0.83, and 0.41 nM, respectively, in CCL39 cells expressing human recombinant receptors).2It inhibits cAMP accumulation induced by forskolin in CCL39 cells expressing human recombinant SST1, SST2, SST3, SST4, and SST5(EC50s = 5.13, 1.91, 6.46, 2.95, and 3.55 nM, respectively).3Somatostatin-28 stimulates growth hormone (GH) release from primary porcine pituitary cells when used at a concentration of 1 fM.4It inhibits acid secretion induced by gastrin I and IBMX in isolated rat gastric mucosa (EC50s = 27 and 252 nM, respectively).5In vivo, somatostatin-28 dose-dependently increases basal and pentagastrin-induced gastric acid secretion in rats.6
1.Lucey, M.R.Endogenous somatostatin and the gutGut27(4)457-467(1986) 2.Siehler, S., Seuwen, K., and Hoyer, D.Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studiesNaunyn Schmiedebergs Arch. Pharmacol.360(5)488-499(1999) 3.Siehler, S., and Hoyer, D.Characterisation of human recombinant somatostatin receptors. 3. Modulation of adenylate cyclase activityNaunyn Schmiedebergs Arch. Pharmacol.360(5)510-521(1999) 4.RamÍrez, J.L., Torronteras, R., CastaÑo, J.P., et al.Somatostatin plays a dual, stimulatory/inhibitory role in the control of growth hormone secretion by two somatotrope subpopulations from porcine pituitaryJ. Neuroendocrinol.9(11)841-848(1997) 5.Wyatt, M.A., Jarvie, E., Feniuk, W., et al.Somatostatin sst2 receptor-mediated inhibition of parietal cell function in rat isolated gastric mucosaBr. J. Pharmacol.119(5)905-910(1996) 6.Seefried, G., Schmidtler, J., and Schwille, P.O.Gastric secretion and gastrin under progressive doses of somatostatin-14 and -28 administered intraperitoneally to the ratPeptides9(2)249-255(1988)
m.cnreagent.com