An active metabolite of quetiapine
货号:ajcx26554
CAS:329218-14-6
分子式:C19H21N3OS • 2HCl
分子量：412.4
溶解度:Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Desethoxy quetiapine is an active metabolite of the atypical antipsychotic quetiapine .¹It is formed from quetiapine primarily by the cytochrome P450 (CYP) isoform CYP3A5 and binds to dopamine D₂receptors (IC₅₀= 1,330 nM).^2,1Desethoxy quetiapine (20 and 40 mg/kg) reduces climbing induced by the dopamine receptor agonist apomorphine in mice. It also improves apomorphine-induced swimming deficits in mice.¹

1.Warawa, E.J., Migler, B.M., Ohnmacht, C.J., et al.Behavioral approach to nondyskinetic dopamine antagonists: Identification of seroquelJ. Med. Chem.44(3)372-389(2001) 2.Bakken, G.V., Rudberg, I., Christensen, H., et al.Metabolism of quetiapine by CYP3A4 and CYP3A5 in presence or absence of cytochrome B5Drug Metab. Dispos.37(2)254-258(2009)