Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor
货号:ajcx26964
CAS:N/A
分子式:C14H20N2O.HCl
分子量：268.78
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor (IC50 values are 145 and 242 nM respectively). Exhibits selectivity for DPP-8/9 over DPP-IV, DPP-2 and FAP.

Lankas et al (2005) Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9. Diabetes 54 2988 PMID:16186403 |Wu et al (2009) Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor. Biochem.Pharmacol. 78 203 PMID:19439267 |Van der Veken et al (2007) Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates. J.Med.Chem. 50 5568 PMID:17958345