MSC1094308 是一种可逆的、II 型 AAA ATPase (VCP)/p97 和I型 AAA ATPase VPS4B 的变构抑制剂，对VPS4B 和 p97 的IC50 值分别为 0.71 μM 和 7.2 μM。
货号:ajcx29526
CAS:2219320-08-6
分子式:C29H29F3N2
分子量：462.55
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MSC1094308 is a reversible and allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B, with IC50 values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively[1].

[1]. PÖhler R, et al. A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1576-1580.