RET-IN-3(compound34)是选择性的RETV804M激酶抑制剂，其IC50值为19nM。
货号:ajcx31402
CAS:2414374-53-9
分子式:C18H21N5O2
分子量：339.39
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

RET-IN-3 (compound 34) is a selective RETV804M kinase inhibitor, with an IC50 of 19 nM[1].

RET-IN-3 exhibits 16 and 410 fold selectivity compared to wt-RET and KDR, respectively[1].

[1]. Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase. ACS Med Chem Lett. 2020 Feb 28;11(4):497-505.