LMP744 HCl (Mj-III65, NSC706744; Mj-III-65, NSC-706744), the hydrochloride salt of LMP744, is a DNA intercalator and Topoisomerase I (Top1) inhibitor with anticancer activity. LMP744 produces persistent topoisomerase I cleavage complexes and can overcome multidrug resistance. Consistent with Top1 poisoning, protein-linked DNA breaks were detected in cells treated with LMP744 at nanomolar concentrations. Studies in human cells in culture found LMP744 to be cytotoxic. Furthermore, limited cross-resistance was observed in camptothecin-resistant cell lines. LMP744 also exhibits antitumor activity in mouse tumor xenografts.

纯度：≥98%

CAS：308246-57-3