T.cruzi-IN-1 是一种有效的克氏锥虫 (Trypanosoma cruzi) 抑制剂，IC50 为 8 nM。T.cruzi-IN-1 是一种 4-三氟甲基取代的类似物，有用于南美锥虫病的急性和慢性阶段的潜力。
货号:ajcx32768
CAS:1350920-22-7
分子式:C22H25F3N2O
分子量：390.44
溶解度:DMSO : 50 mg/mL (128.06 mM; ultrasonic and warming and heat to 60буC)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

T.cruzi-IN-1 is a potent Trypanosoma cruzi inhibitor with an IC50 of 8 nM. T.cruzi-IN-1, a 4-trifluoromethyl substituted analog, has the potential for both the acute and chronic stages of Chagas disease[1].

T.cruzi-IN-1 inhibits Trypanosoma cruzi replication and has an IC50 of 61.6 µM for toxicity[1].

参考文献:
[1]. Germain AR, et al. Identification of small-molecule inhibitors of Trypansoma cruzi replication. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7197-200.