AI-10-47 是 CBFβ-RUNX 结合的小分子抑制剂，其 IC50 值为 3.2 μM。
货号:ajcx33350
CAS:1256094-31-1
分子式:C13H8F3N3O
分子量：279.22
溶解度:DMSO : 100 mg/mL (358.14 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding, with an IC50 of 3.2 μM[1].

AI-10-47 (10 μM) weakly inhibits CBFβ-RUNX binding[1].AI-10-47 significantly inhibits ME-1, TUR, M0-91, THP-1 and U937 cell growth[1].

[1]. Anuradha Illendula, et al. Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers. EBioMedicine. 2016 Jun;8:117-131.