CD73-IN-3 是一种有效的 CD73 抑制剂(IC50; Calu6 人细胞实验中)。CD73-IN-3，例 2 源自专利 WO2019168744 A1，具有研究癌症的潜力。
货号:ajcx33510
CAS:2375815-63-5
分子式:C15H18N4O2
分子量：286.33
溶解度:DMSO : 100 mg/mL (349.25 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CD73-IN-3 is a potent CD73 inhibitor (IC50=7.3 nM in Calu6 human cell assay). CD73-IN-3, example 2 extracted from patent WO2019168744 A1, has the potential for cancer research[1].

CD73-IN-3 inhibits CD73 activity in human serum with an EC50 of 0.213 μM. CD73-IN-3 inhibits CD73 activity in human serum by 56.8%, 71.7% and 76.9% at 0.52 μM, 1.56 μM, 4.68 μM,respectively[1].In Calu6 human cell assay against CD73, the IC50 for CD73-IN-3 against CD73 is 0.0073 uM[1].

[1]. Robert Dean Dally, et al. Cd73 inhibitors. Patent WO2019168744 A1.