Izilendustat 是一种有效的脯氨酰羟化酶 (prolyl hydroxylase) 抑制剂，可稳定缺氧诱导因子-1 α (HIF-1α) 和缺氧诱导因子-2 (HIF-2)。Izilendustat 具有研究与身体免疫反应相关的疾病的潜力，如结肠炎和其他炎症性肠病 (提取自专利 WO2011057115A1 和 WO2011057121A1)。
货号:ajcx36436
CAS:1303512-02-8
分子式:C22H28ClN3O4
分子量：433.93
溶解度:DMSO : 25 mg/mL (57.61 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Izilendustat is a potent inhibitor of prolyl hydroxylase which can stabilize hypoxia inducible factor- 1 alpha (HIF- lα) and hypoxia inducible factor-2 (HIF-2). Izilendustat has the potential for researching diseases that relate to the body’s inmmune response like colitis and other inflammatory bowel diseases (extracted from patent WO2011057115A1 and WO2011057121A1)[1][1].

[1]. Joseph H, et al. Prolyl hydroxylase inhibitors. Patent WO2011057115A1. [2]. Joseph H, et al. Compositions and methods for treating colitis. Patent WO2011057121A1.