KH-CB20，一种 E/Z 混合物，是有效和选择性的 CLK1 和密切相关的同工型 CLK4 的抑制剂，抑制 CLK1 的 IC50 值为 16.5 nM。KH-CB20 还可以抑制 DYRK1A (IC50=57.8 nM) 和 CLK3 (IC50=488 nM)。
货号:ajcx36664
CAS:1354448-60-4
分子式:C15H13Cl2N3O2
分子量：338.19
溶解度:DMSO : 100 mg/mL (295.69 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

KH-CB20, an E/Z mixture, is a potent and selective inhibitor of CLK1 and the closely related isoform CLK4, with an IC50 of 16.5 nM for CLK1. KH-CB20 can also inhibit DYRK1A (IC50=57.8 nM) and CLK3 (IC50=488 nM)[1].

KH-CB20 shows selectivity for CLK1 (IC50=16.5 nM) over DYRK1A (IC50=57.8 nM) and CLK3 (IC50=488 nM)[1].

[1]. Fedorov O, et, al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011 Jan 28;18(1):67-76.