Samatasvir (IDX71) 是一种有效的，具有口服活性的 NS5A HCV 复制抑制剂。Samatasvir 对感染性 HCV 和复制子有效且有选择性，在基因型 1至5 复制子中，EC50 在 2 至 24 pM 的范围内。
货号:ajcx36804
CAS:1312547-19-5
分子式:C47H48N8O6S2
分子量：885.06
溶解度:DMSO : 50 mg/mL (56.49 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Samatasvir (IDX71) is a potent, orally active NS5A inhibitor of HCV replication. Samatasvir is effective and selective against infectious HCV and replicons, with EC50s falling within a tight range of 2 to 24 pM in genotype 1 through 5 replicons[1].

Samatasvir (IDX719) retains full activity in the presence of HIV and hepatitis B virus (HBV) antivirals and is not cross-resistant with HCV protease, nucleotide, and nonnucleoside polymerase inhibitor classes[1].

[1]. Bilello JP, et al. In vitro activity and resistance profile of samatasvir, a novel NS5A replication inhibitor of hepatitis C virus. Antimicrob Agents Chemother. 2014;58(8):4431-4442.