Ubiquitination-IN-1 (compound 24) 是泛素化 (ubiquitination) 和 Cksl-Skp2 蛋白互作抑制剂 (IC50=0.17 μM) 抑制剂，增加 p27 水平。Ubiquitination-IN-1 可通过阻断肿瘤抑制因子的降解来用于疾病。
货号:ajcx36838
CAS:1819330-15-8
分子式:C21H14F3N3O2S
分子量：429.41
溶解度:DMSO : 83.33 mg/mL (194.06 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Ubiquitination-IN-1 (compound 24) is a ubiquitination and Cksl-Skp2 protein-protein interaction (IC50=0.17 μM) inhibitor. Ubiquitination-IN-1 increases levels of p27. Ubiquitination-IN-1 has the potential for treatment disease by blocking the degradation of tumor suppressors[1].

Ubiquitination-IN-1 inhibits A549 and HT1080 cells with IC50s of 0.91 and 0.4 μM, respectively[1].

[1]. David Carroll, et al.Quinoline derivatives useful as ubiquitination inhibitors. WO2016025779A1.