NCGC00229600 是 TSHR 的变构反向激动剂。NCGC00229600 抑制 TSH 和刺激在 Graves 病中内源表达的 TSHRs 的抗体激活。
货号:ajcx36924
CAS:1338824-20-6
分子式:C30H29N3O3
分子量：479.57
溶解度:DMSO : 50 mg/mL (104.26 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

NCGC00229600 is an allosteric inverse agonist of thyrotropin receptor (TSHR). NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously expressed in Graves’ disease[1].

[1]. Neumann S, et al. A new small-molecule antagonist inhibits Graves’ disease antibody activation of the TSH receptor. J Clin Endocrinol Metab. 2011 Feb;96(2):548-54.