NCT02 是一种细胞周期蛋白 K 降解剂。NCT02 诱导细胞周期蛋白 K (CCNK) 的泛素化和 CCNK 及其复合物 CDK12 的蛋白酶体降解。NCT02具有研究转移性结直肠癌 (CRC) 的潜力。
货号:ajcx37526
CAS:790245-61-3
分子式:C17H16N2O2S
分子量：312.39
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

NCT02 is a cyclin K degrader. NCT02 induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12. NCT02 has the potential for the research of metastatic colorectal cancer (CRC)[1].

[1]. Dieter SM, et al. Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. Cell Rep. 2021;36(3):109394.