ML198 是一种葡萄糖脑苷脂酶 (GCase) 调节剂，EC50 为 0.4 μM。ML198 是葡萄糖脑苷脂酶的激活剂和非抑制性伴侣。ML198 可用于戈谢病的研究。
货号:ajcx37752
CAS:1380716-06-2
分子式:C17H14N4O
分子量：290.32
溶解度:DMSO : 5 mg/mL (17.22 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease[1].

ML198 is stable in D-PBS pH 7.4 at room temperature over 48 hr[1].ML198 increases translocation of GCase to the lysosome (20% cell translocation at 5 µM, compared to 5% of DMSO) in human fibroblasts[1].ML198 shows promising microsomal stability and Caco-2 permeability, with low water solubility[1].

[1]. Steven Rogers, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase.