NITD-2 是登革病毒 (DENV) 聚合酶抑制剂，抑制DENV RdRp 蛋白介导的 RNA 延伸。NITD-2 的细胞膜透过性较差。
货号:ajcx37850
CAS:1197896-79-9
分子式:C23H19N3O4S
分子量：433.48
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

NITD-2, a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly[1].

NITD-2 inhibits de novo RNA synthesis[1].NITD-2 exhibited no antiviral activity in cell culture resulted from the poor cell penetratration[1].

[1]. Pornwaratt Niyomrattanakit, et al. Inhibition of dengue virus polymerase by blocking of the RNA tunnel. J Virol. 2010 Jun;84(11):5678-86.