Cibenzoline 是一种有效的 KATP 通道抑制剂，直接影响成孔的 Kir6.2 亚基而不是 SUR1 亚基。Cibenzoline 是 Ia 类抗心律失常药物。Cibenzoline 几乎没有抗胆碱能活性。Cibenzoline 显着减弱 LVPG，与心肌收缩力下降有密切关系。Cibenzoline 具有用于肥厚型梗阻性心肌病研究的潜力。
货号:ajcx38568
CAS:53267-01-9
分子式:C18H18N2
分子量：262.35
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Cibenzoline is a potent inhibitor of KATP channel with directly affecting the pore-forming Kir6.2 subunit rather than the SUR1 subunit. Cibenzoline is a class Ia antiarrhythmic drug. Cibenzoline has little anticholinergic activity. Cibenzoline markedly attenuate LVPG which has a close relationship with myocardial contractility decreasing. Cibenzoline has the potential for the research of hypertrophic obstructive cardiomyopathy[1][2].

[1]. Mukai E, et al. The antiarrhythmic agent cibenzoline inhibits KATP channels by binding to Kir6.2. Biochem Biophys Res Commun. 1998;251(2):477-481.
[2]. Hamada M, et al. Class Ia antiarrhythmic drug cibenzoline: a new approach to the medical treatment of hypertrophic obstructive cardiomyopathy. Circulation. 1997;96(5):1520-1524.