ODM-203 是一种有效的 FGFR 和 VEGFR 家族的抑制剂，对 FGFR1、FGFR2、FGFR3、FGFR4 的 IC50 值分别为 11 nM, 16 nM, 6 nM, 35 nM，对 VEGFR1、VEGFR2、VEGFR3 的 IC50 值分别为 26 nM, 9 nM, 5 nM。ODM-203 具有很强的抗肿瘤活性并诱导抗肿瘤免疫。
货号:ajcx38618
CAS:1430723-35-5
分子式:C26H21F2N5O2S
分子量：505.54
溶解度:DMSO : 66.67 mg/mL (131.88 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ODM-203 is a potent FGFR and VEGFR families inhibitor with IC50s of 11, 16, 6, 35 nM towards recombinant FGFR1, FGFR2, FGFR3 and FGFR4 as well as 26, 9, 5 nM towards VEGFR1, VEGFR2 and VEGFR3, respectively. ODM-203 exhibits strong anti-tumor activity and induces anti-tumor immunity[1].

[1]. HolmstrÖm TH, et al. ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity. Mol Cancer Ther. 2019 Jan;18(1):28-38.

Protocol:

FGFR1 11nM(IC50)

FGFR2 16nM(IC50)

FGFR3 6nM(IC50)

FGFR4 35nM(IC50)

VEGFR1 26nM(IC50)

VEGFR2 9nM(IC50)

VEGFR3 5nM(IC50)

DDR1 6nM(IC50)

RET 8nM(IC50)

SIK3 23nM(IC50)

PDGFRa 35nM(IC50)

MINK1 41nM(IC50)

MAP4K4 49nM(IC50)