Spastazoline 是一种有效、选择性的 spastin (一种微管切断 AAA 蛋白) 抑制剂，对人 spastin 的 IC50 值为 99 nM。Spastazoline 对重组人 VPS4 的 ATPase 活性没有作用。
货号:ajcx38642
CAS:2351882-11-4
分子式:C20H30N8
分子量：382.51
溶解度:DMSO : 100 mg/mL (261.43 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Spastazoline is a potent and selective spastin (a microtubule-severing AAA protein) inhibitor, with an IC50 of 99 nM for Human spastin. Spastazoline shows no effect on ATPase activity of a recombinant human VPS4[1].

[1]. Cupido T, et al. Designing a chemical inhibitor for the AAA protein spastin using active site mutations. Nat Chem Biol. 2019 Feb 18.