ZL0454是有效，选择性的含有溴结构域的蛋白质4 (BRD4)抑制剂，对BD1和BD2的IC50分别为49和32 nM 。
货号:ajcx39122
CAS:2229042-77-5
分子式:C18H22N4O3S
分子量：374.46
溶解度:DMSO : 50 mg/mL (133.53 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ZL0454 is a potent and selective Bromodomain-containing protein 4 (BRD4) inhibitor with an IC50 of 49 and 32 nM for BD1 and BD2.

[1]. Liu Z, et al. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur J Med Chem. 2018 May 10;151:450-461.