NRX-252262 是一种有效的 β-Catenin 与 同源 E3 ligase SCFβ-TrCP 的相互作用增强剂，能够促进 β-catenin 的降解，EC50 值为 3.8 nM。
货号:ajcx39382
CAS:2438637-61-5
分子式:C23H17Cl2F3N2O4S
分子量：545.36
溶解度:DMSO : 8.33 mg/mL (15.27 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM[1].

NRX-252262 (35 μM) causes S33E/S37A mutant β-catenin degradation in cells[1].

[1]. Kyle R. Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications. 2019 March.