| 规格: | 98% |
| 分子量: | 375.55 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
Background:
AXKO-0046 is an indole derivative and small-molecule LDHB selective inhibitor.
AXKO-0046 has selectivity and highly potent LDHB inhibitory activity with an value EC50 of 42 nM. AXKO-0046 bounds to the potential allosteric site away from the LDHB catalytic active site. AXKO-0046 can be used to validate LDHB associated pathways in cancer metabolism[1].
[1]. Sachio Shibata, et al. Identification of the first highly selective inhibitor of human lactate dehydrogenase B. Sci Rep. 2021 Nov 1;11(1):21353.
m.cnreagent.com