| 规格: | 98% |
| 分子量: | 464.32 |
| 包装 | 价格(元) |
| 250mg | 电议 |
| 500mg | 电议 |
Background:
2-Keto Crizotinib (PF-06260182) is an active lactam metabolite of crizotinib.
2-Keto Crizotinib (PF-06260182) is active and considerably less potent than crizotinib, and it is not thought to contribute significantly to the in vivo activity of crizotinib.
[1]. Balis FM, e al. First-dose and steady-state pharmacokinetics of orally administered crizotinib in children with solid tumors: a report on ADVL0912 from the Children's Oncology Group Phase 1/Pilot Consortium. Cancer Chemother Pharmacol. 2017 Jan;79(1):181-187.
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