Fumaratehydratase是TCA循环的一种酶。
货号:ajcx13474
CAS:N/A
分子式:C25H25N2NaO4
分子量：440.47
溶解度:DMSO : 10.66 mg/mL (24.20 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

.Fumarate hydratase is an enzyme of the TCA cycle and cell-permeable inhibitors (1) inhibition of fumarate hydratase can contribute to tumorigenicity in some cells. (2) The use of a photoaffinity labeling strategy identified fumarate hydratase as the principal pharmacological target. Final biochemical studies confirmed dose-dependent, competitive inhibition of this enzyme (3) Chemical inhibition of fumarate hydratase renders cells highly dependent on glucose metabolism for survival.

[1]. Takeuchi T et al. Identification of fumarate hydratase inhibitors with nutrient-dependent cytotoxicity. J Am Chem Soc. 2015 Jan 21;137(2):564-7.