Bobcat339hydrochloride是基于胞嘧啶的TET酶抑制剂，对TET1和TET2的IC50值分别33μM和73μM。它可用于表观遗传学领域研究，并且可作为靶向DNA甲基化和基因转录新疗法的起点。
货号:ajcx13582
CAS:N/A
分子式:C16H13Cl2N3O
分子量：334.2
溶解度:DMSO : 130 mg/mL (388.99 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Bobcat339 hydrochloride is a cytosine-based TET enzyme inhibitor with IC50 of 33 μM (TET1) and 73 μM (TET2). It is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription. IC50: 33 μM (TET1), 73 μM (TET1)[1]

[1]. Chua GNL, et al. Cytosine-Based TET Enzyme Inhibitors. ACS Med Chem Lett. 2019 Jan 31;10(2):180-185.