TMP920 是一个高效、选择性的 RORγt 拮抗剂。TMP920 抑制 RORγt 结合 SRC1 肽的 IC50 值为 0.03 μM。
货号:ajcx16372
CAS:1421837-45-7
分子式:C29H30N2O3
分子量：454.56
溶解度:DMSO: 62.5 mg/mL (137.50 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC50 of 0.03 μM[1].

[1]. Xiao S, et al. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity. 2014 Apr 17;40(4):477-89.