RET V804M-IN-1 (compound 5) 是 wt-RET 选择性的 RETV804M 激酶抑制剂，其 IC50 值为 20 nM。
货号:ajcx29650
CAS:2414909-94-5
分子式:C19H16N6O
分子量：344.37
溶解度:DMSO: 125 mg/mL (362.98 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

RET V804M-IN-1 (compound 5) is a wt-RET -selective inhibitors of RETV804M kinase, with an IC50 of 20 nM[1].

RET V804M-IN-1 (compound 5) exhibits 3.7 and 110 fold selectivity compared to wt-RET and KDR, respectively[1].

[1]. Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase. ACS Med Chem Lett. 2020 Feb 28;11(4):497-505.