WDR5-IN-4TFA是一种染色质相关WD重复结构域5蛋白(WDR5)的WIN位点抑制剂，Kd值为0.1nM。WDR5-IN-4TFA能够从染色质中取代WDR5，并降低相关基因的表达，引起翻译抑制和核仁应激。具有抗癌作用。
货号:ajcx31664
CAS:N/A
分子式:C27H23Cl2F4N5O3
分子量：612.4
溶解度:DMSO: ≥ 250 mg/mL (408.23 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

WDR5-IN-4 TFA is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WDR5-IN-4 TFA displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity[1].

[1]. Aho ER, et al. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.