X5050 是 REST 的一个抑制剂，其 EC50 值为 2.1 μM。
货号:ajcx32912
CAS:2404756-81-4
分子式:C17H15N3O3
分子量：309.32
溶解度:DMSO : 100 mg/mL (323.29 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

X5050 is a REST inhibitor, with an EC50 of 2.1 μM[1].

X5050 (100 µM, 1 day) induces a dosedependent decrease in the REST isoform in protein level[1].

X5050 (2 x 2µl of 20 mM) is active in HD pathological context[1].

[1]. JÉrÉmie Charbord, et al. High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes. Stem Cells. 2013 Sep;31(9):1816-28.