PIK-108 是一种非 ATP 竞争性的，变构的 p110β/p110δ 选择性抑制剂。
货号:ajcx33528
CAS:901398-68-3
分子式:C22H24N2O3
分子量：364.44
溶解度:DMSO : 50 mg/mL (137.20 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PIK-108 is a non-ATP competitive, allosteric p110β/p110δ selective inhibitor[1].

PIK-108 (0.1-10 μM; 1 hour) blocks phosphorylation of PKB/Akt[1].

[1]. Zachary A Knight, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47.
[2]. Jack S Chen, et al. Characterization of structurally distinct, isoform-selective phosphoinositide 3’-kinase inhibitors in combination with radiation in the treatment of glioblastoma. Mol Cancer Ther. 2008 Apr;7(4):841-50.