Brr2-IN-3 是一种有效的选择性 Brr2 解旋酶变构抑制剂。Brr2-IN-3 抑制解旋酶活性的 IC50 值为 1.3 μM，且呈剂量依赖性。
货号:ajcx34588
CAS:2104030-82-0
分子式:C24H20N4O3S
分子量：444.51
溶解度:DMSO : 50 mg/mL (112.48 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Brr2-IN-3 is a potent and selective Brr2 helicase allosteric Inhibitor. Brr2-IN-3 inhibits helicase activity in dose-dependent manner with an IC50 value of 1.3 μM[1].

[1]. Iwatani-Yoshihara M, et al. Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2. J Med Chem. 2017;60(13):5759-5771.