CRA-2059 是一种特异性、选择性的类胰蛋白酶 (tryptase) 抑制剂，对重组人类胰蛋白酶-β (rHTβ) 的 Ki 为 620 pM。
货号:ajcx34648
CAS:N/A
分子式:C36H47F3N12O10
分子量：864.83
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].

Tryptase is a trypsin-like serine protease found as a major protein component in human mast cell secretory granules. CRA-2059 has the potential for inflammatory bowel disease research[1].

[1]. Tremaine WJ, et al. Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study. Aliment Pharmacol Ther. 2002;16(3):407-413.
[2]. Selwood T, et al. Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor. Biol Chem. 2003;384(12):1605-1611.