PF-05381941 是一种有效的 TAK1/p38α 双抑制剂，IC50 值分别为 156 和 186 nM。
货号:ajcx35102
CAS:1474022-02-0
分子式:C27H26N6O2
分子量：466.53
溶解度:DMSO : 100 mg/mL (214.35 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PF-05381941 is a potent dual inhibitor of TAK1/p38α, with IC50s of 156 and186 nM, respectively[1].

PF-05381941 inhibits LPS-stimulated release of TNF-αfrom human peripheralmononuclear (PMN) cells with an IC50 of 8 nM[1].

[1]. Kilty I, et al. TAK1 inhibition in the DFG-out conformation. Chem Biol Drug Des. 2013;82(5):500-505.