246C10 是一种合成的可电离脂质。246C10 可以与二油基磷脂酰乙醇胺 (DOPE)、胆固醇、C16-PEG2000神经酰胺 (PEG-lipid) 以及mRNA一起被配制成脂质纳米粒 (LNP)。脂质纳米粒制剂可用于 mRNA 递送。
货号:ajcx36746
CAS:2635329-26-7
分子式:C58H120N4O4
分子量：937.6
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

246C10 is a synthesized ionizable lipid. 246C10 can be formulated into lipid nanoparticles (LNPs) with dioleoylphosphatidylethanolamine (DOPE), cholesterol, and C16-PEG2000 ceramide (PEG-lipid) as well as mRNA. The lipid nanoparticle formulations can be used for mRNA delivery[1].

[1]. Kim M, et al. Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver. Sci Adv. 2021;7(9):eabf4398. Published 2021 Feb 26.