M1001 是一种较弱的 HIF-2α 激动剂，直接与 HIF-2α PAS-B 结构域结合，Kd 值为 667 nM。M1001 能够增强 HIF-2α-ARNT 复合体之间的稳定性。
货号:ajcx38608
CAS:874590-32-6
分子式:C17H17N3O2S
分子量：327.4
溶解度:DMSO : 250 mg/mL (763.59 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

M1001 is a weak agonist of HIF-2α, directly binds to the HIF-2α PAS-B domain, with a Kd of 667 nM. M1001 enhances the stabilities of HIF-2α-ARNT complex[1].

[1]. Wu D, et al. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat Chem Biol. 2019 Feb 25.