Description: Quisinostat HCl (formerly JNJ-26481585; JNJ 26481585; JNJ26481585), the hydrochloride salt of Quisinostat, is an orally bioavailable, 2nd generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antitumor activity. It inhibits HDAC with IC50 of 0.11 nM for HDAC1.

References: Clin Cancer Res. 2009 Nov 15;15(22):6841-51; Br J Haematol. 2010 May;149(4):529-36.

Related CAS #: 1083078-98-1 (HCl); 875320-29-9 (free base); 875320-31-3 (2HCl)