VU6012962是一种口服生物可利用的，可渗透CNS的，代谢型谷氨酸受体7(mGlu7)阴性变构调节剂(NAM)，IC50为347nM。
货号:ajcx13368
CAS:N/A
分子式:C21H19F3N4O4
分子量：448.4
溶解度:DMSO : 125 mg/mL (278.77 mM);H2O :< 0.1 mg/mL (insoluble)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 (mGlu7) negative allosteric modulator (NAM) with an IC50 of 347 nM[1].

[1]. Reed CW, et al. Discovery of an orally bioavailable and Central Nervous System (CNS) penetrant mGlu7 NegativeAllosteric Modulator (NAM) in vivo tool compound: N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962). J Med Chem. 2019 Jan 4.