Epertinib hydrochloride 是一种有效，可口服，可逆的，选择性的 EGFR，HER2 和 HER4 抑制剂，IC50 值分别为 1.48 nM，7.15 nM 和 2.49 nM。Epertinib 具有高效的抗肿瘤活性。
货号:ajcx14664
CAS:2071195-74-7
分子式:C30H28Cl2FN5O3
分子量：596.48
溶解度:DMSO: 125 mg/mL (209.56 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively. Epertinib shows potent antitumor activity[1].

[1]. [1]. Tanaka H, et al. Preclinical antitumor activity of S-222611, an oral reversible tyrosine kinase inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor 2. Cancer Sci. 2014 Aug;105(8):1040-8.