DPA-714 是一种高亲和力的移位蛋白 (TSPO) 配体 (Ki=7 nM)，DPA-714 的结构中有一个氟原子，允许用氟 -18 进行标记，并可使用正电子发射断层成像进行活体成像。[18F]DPA-714 在各种神经炎症模型和脑肿瘤模型中成功评估炎症的特异性成像。
货号:ajcx14726
CAS:958233-07-3
分子式:C22H27FN4O2
分子量：398.47
溶解度:DMSO: 41.67 mg/mL (104.57 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. [18F]DPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model[1][2].

[1]. James ML, et al. DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization. J Nucl Med. 2008 May;49(5):814-22. [2]. Harhausen D, et al. Specific imaging of inflammation with the 18 kDa translocator protein ligand DPA-714 in animal models of epilepsy and stroke. PLoS One. 2013 Aug 2;8(8):e69529.