BTdCPU 是有效的血红素调节的 eIF2α 激酶 (HRI) 激活剂。BTdCPU 促进耐药细胞中 eIF2α 磷酸化并诱导凋亡。
货号:ajcx14826
CAS:1257423-87-2
分子式:C13H8Cl2N4OS
分子量：339.2
溶解度:DMSO: ≥ 250 mg/mL (737.03 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell[1].

[1]. Burwick N, et al. The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma. Leuk Res. 2017 Apr;55:23-32.