Giredestrant (GDC-9545) 是一种非甾体 ER 配体，口服有效的，选择性雌激素受体 (ER) 拮抗剂。Giredestrant 可以在 ER 配体结合域内与雌二醇竞争结合并诱导构象变化。Giredestrant 具有抗肿瘤活性。
货号:ajcx16996
CAS:1953133-47-5
分子式:C27H31F5N4O
分子量：522.55
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Giredestrant (GDC-9545), a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist. Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity[1].

[1]. C Metcalfe, et al. Abstract P5-04-07: GDC-9545: A novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes