Navitoclax-piperazine (ABT-263-piperazine) 是一种特大型 B 细胞淋巴瘤 (BCL-XL) 抑制剂。Navitoclax-piperazine 和 E3 泛素连接酶的 VHL 配体可用来合成 PROTAC DT2216 。
货号:ajcx17034
CAS:2143096-93-7
分子式:C47H56ClF3N6O5S3
分子量：973.63
溶解度:DMSO: 250 mg/mL (256.77 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor. Navitoclax-piperazine and a VHL ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC DT2216 [1].

[1]. Sajid Khan, et al. A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nat Med 25, 1938-1947 (2019).