SGC AAK1 1 是一种有效的选择性 AAK1（AP2 相关激酶 1）抑制剂，IC50 为 270 nM，Ki 为 9 nM。 SGC AAK1 1 也有效抑制 BMP2K。 SGC AAK1 1 用于研究与 AAK1 相关的 Wnt 通路。
货号:ajcx27656
CAS:2247894-32-0
分子式:C21H25N5O3S
分子量：427.52
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Adaptor-associated protein kinase 1 (AAK1) and BMP-2-inducible protein kinase (BMP2K) inhibitor (IC50 values are 233 nM and 1.48 μM for AAK1 and BMP2K, respectively). Inhibits AAK1-dependent phosphorylation of AP2M1. Activates Wnt signaling.

Agajanian et al (2018) AAK1 inhibits WNT signaling by promoting clathrin-mediated endocytosis of LRP6. View pre-publication manuscript.