TAK-615是一种LPA1受体的负变构调节剂(NAM)，用于研究肺纤维化。TAK-615高亲和力结合LPA1受体(Kd高亲和力为1.7nM，Kd低亲和力为14.5nM)。
货号:ajcx31540
CAS:1664335-55-0
分子式:C25H22FNO4
分子量：419.44
溶解度:DMSO: 125 mg/mL (298.02 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TAK-615 is a negative allosteric modulator (NAM) of the LPA1 receptor for the research of pulmonary fibrosis. TAK-615 binds the LPA1 receptor with high affinity (Kd high affinity of 1.7 nM and Kd low affinity of 14.5 nM)[1].

TAK-615 partially inhibits the LPA response (60% at 10 µM, IC50 of 91±30 nM)[1].

[1]. Jonathan Ellery, et al. Identification of Compounds Acting as Negative Allosteric Modulators of the LPA 1 Receptor. Eur J Pharmacol. 2018 Aug 15;833:8-15.